On A1 exit at "Chiusi - Chianciano terme", follow the indication for Sarteano/Radicofani. Follow the indication for Sorano then S.Quirico. When you arrive at S.Quirico, follow the indication for Manciano
Alternative on A1 exit at "Firenze Impruneta" and take the superstrada for Siena, at Siena take the via SS2 Cassia in the direction Roma. Follow the indication for Sorano, then S. Quirico.
When you arrive in S.Quirico follow the indication for Manciano.

On A1 exit at Orvieto, follow the indication for Pitigliano / Saturnia

ON SS1 Aurelia exit at Albinia or at Fonteblanda follow the indication for Manciano and Pitigliano.

On E45 exit at Todi follow the indication for Orvieto, when you arrive at Orvieto follow the indication for Pitigliano / Saturnia

Decimal Degrees:
Latitude: 42.62375919999999
Longitude: 11.660092299999974
Degrees, Minutes, Seconds:
Latitude: 42° 37' 25.533''
Longitude: 11° 39' 36.332''